ea0090p275 | Adrenal and Cardiovascular Endocrinology | ECE2023
Mangone Alessandra
, Altieri Barbara
, Detomas Mario
, Prete Alessandro
, Abbas Haider
, Felicitas Asia Miriam
, Elhassan Yasir
, Mantovani Giovanna
, Ronchi Cristina
Background: Treatment for advanced adrenocortical carcinoma (ACC) consists of mitotane alone or combined with etoposide, doxorubicin and cisplatin (EDP), yet their efficacy is limited and burdened with significant toxicity. Moreover, markers of response are lacking. Inflammation-based scores have been proposed as prognostic factors in several malignancies including ACC, and recently also as predictors of gemcitabine+capecitabine efficacy, second-line treatment in progressive d...